Bradykinin Quantification
Bradykinins are short-lived peptides of the Kallikrein–Kinin System (KKS) that play key roles in vascular regulation, inflammation, and endothelial function. Accurate measurement of these labile peptides provides unique insights into enzymatic activity, pathway dynamics, and drug effects.
Attoquant Diagnostics delivers precise, reproducible quantification of bradykinins in plasma, tissues, and other biological matrices. All assays are performed using high-sensitivity LC-MS/MS with stable isotope-labeled standards, ensuring specificity and reliability across all measurements.
Why Bradykinin Measurement is Challenging
Bradykinins have extremely short half-lives and are rapidly metabolized.
This makes them difficult to capture reliably using conventional methods.
Variability during sampling and the presence of multiple metabolizing enzymes can lead to inconsistent data, especially when comparing across studies.
Our Solution
We use optimized sampling protocols, enzyme inhibitors, and state-of-the-art LC-MS/MS quantification to measure bradykinin peptides and their metabolites with high precision.
Our approach allows you to confidently monitor:
- Vascular and inflammatory responses
- Drug effects on the KKS (e.g., ACE inhibitors)
- Pathway activation in cardiovascular, renal, or inflammatory models
Our Bradykinin-Services
Our Bradykinin-Services
We routinely quantify the full spectrum of bradykinin peptides across the Kallikrein– Kinin System using high-sensitivity LC-MS/MS.
The overview above illustrates all bradykinins included in our standard analytical workflow, enabling comprehensive assessment of pathway activity and peptide turnover in biological samples.
All measurements are performed using optimized sampling protocols and stable isotope-labeled internal standards to ensure specificity, robustness, and reproducibility.
Extended Applications & Project Support
Our standard workflow already covers the full spectrum of bradykinin peptides.
For specialized study designs — such as additional analytes, uncommon species, combined pathway analyses, or pharmacokinetic applications — our team provides tailored assay adaptations, sampling guidance, and
expert data interpretation.
Contact us today to discuss your project or request a quote.
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Attoquant Diagnostics GmbH
Brehmstraße 14A
1110 Vienna
Austria
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Tel: 0043 (0)660 668 58 96
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