Publications & Studies

Publications 2026

Kovarik et al. Fulacimstat Reduces Angiotensin II in Kidney Allografts in a Cross-Sectional Exploratory Study. Kidney Int Rep. 2025 Dec 24;11(3):103745. PUBMED ID: 41624455

Kaiser-Graf et al. Upregulation of angiotensin-(1-7) formation in human podocytes – enzyme activity assay upon fluid flow shear stress. PLoS One. 2026 Jan 9;21(1):e0339874. PUBMED ID: 41511943

Publications 2025

Weitzhandler et al. Myocardial and Renal Renin-Angiotensin System Enzyme Activity in Dogs. J Vet Intern Med. 2025 Jul-Aug;39(4):e70181. PUBMED ID: 40601867

Holbrook et al. Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise. J Vet Intern Med. 2025 Mar-Apr;39(2):e70036. PUBMED ID: 40048547

Leinweber et al. Angiotensin Dysregulation in Patients with Arterial Aneurysms. Int J Mol Sci. 2025 Feb 11;26(4):1502. PUBMED ID: 40003968

Hochreiter et al. Characterizing SV40-hTERT Immortalized Human Lung Microvascular Endothelial Cells as Model System for Mechanical Stretch-Induced Lung Injury. Int J Mol Sci. 2025 Jan 15;26(2):683. PUBMED ID: 39859396

Krenn et al. Renin-angiotensin-aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study. Ann Intensive Care. 2025 Jan 16;15(1):10. PUBMED ID: 39821855

Wolf et al. Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH dependent Cushing’s syndrome. Endocr Connect. 2025 Jan 1:EC-24-0617. PUBMED ID: 39804209

Manson et al. Dose-exposure-response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin-angiotensin-aldosterone system in healthy dogs. JJ Vet Intern Med. 2025 Jan-Feb;39(1):e17255. PUBMED ID: 39601373

Publications 2024

Rodrigues et al. Renin Is Essential for Angiotensin II Formation in the Brain. J Am Heart Assoc. 2024 Nov 19;13(22) PUBMED ID: 39547965

Lehman et al. Effect of furosemide on comprehensive renin-angiotensin-aldosterone system activity of Thoroughbred horses. J Vet Intern Med. 2024 Oct 22. PUBMED ID: 39434560

Wopperer et al. Progressive Kidney Failure by Angiotensinogen Inactivation in the Germline. Hypertension. 2024 Sep;81(9):1857-1868. PUBMED ID: 39005223

Krenn et al. Intra- and postoperative relative angiotensin II deficiency in patients undergoing elective major abdominal surgery. Front Endocrinol (Lausanne). 2024 Jul 8:15:1375409. PUBMED ID: 39040679

Rodrigues et al. Angiotensin-(1-12): Does It Exist? A Critical Evaluation in Humans, Rats, and Mice. Hypertension. 2024 May 8. PUBMED ID: 38716648

Cruz-López et al. Combining renin-angiotensin system blockade and sodium-glucose cotransporter-2 inhibition in experimental diabetes results in synergistic beneficial effects. J Hypertens. 2024 May 1;42(5):883-892. PUBMED ID: 38088400

Simko et al. Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system. Biomed Pharmacother. 2024 Apr:173:116391. PUBMED ID: 38461685

Masters et al. Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs. PLoS One. 2024 Feb 23;19(2):e0298030. PUBMED ID: 38394253

Marrero et al. Effect of amlodipine on the circulating renin-angiotensin-aldosterone system in healthy cats. J Vet Intern Med. 2024 Feb 9. doi: 10.1111/jvim.17006. PUBMED ID: 38334012

Baumgartner et al. Profiling endogenous adrenal function during veno-venous ECMO support in COVID-19 ARDS: a descriptive analysis. Front Endocrinol (Lausanne). 2024 Jan 25:14:1321511. PUBMED ID: 38333725

Publications 2023

Adin et al. Evaluation of Renin-Angiotensin-Aldosterone System Components and Enzymes in Systemically Hypertensive Cats Receiving Amlodipine. Animals (Basel). 2023 Nov 10;13(22):3479. PUBMED ID: 38003097

Shoemaker et al. Association of Elevated Serum Aldosterone Concentrations in Pregnancy with Hypertension. Biomedicines. 2023 Nov 1;11(11):2954. PUBMED ID: 38001956

Rathkolb et al. Renin-angiotensin system inhibitor discontinuation in COVID-19 did not modify systemic ACE2 in a randomized controlled trial. iScience. 2023 Oct 5;26(11):108146. PUBMED ID: 37867935

Dengler et al. Dysregulation of intestinal epithelial electrolyte transport in canine chronic inflammatory enteropathy and the role of the renin-angiotensin-aldosterone-system. Front Vet Sci. 2023 Aug 31:10:1217839. PUBMED ID: 37720474

Shoemaker et al. Activation of the Renin-Angiotensin-Aldosterone System Is Attenuated in Hypertensive Compared with Normotensive Pregnancy. Int J Mol Sci. 2023 Aug 12;24(16):12728. PUBMED ID: 37628909

Dube et al. Novel Model of Oxalate Diet-Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats. Int J Mol Sci. 2023 Jun 13;24(12):10062. PUBMED ID: 37373209

Arisido et al. Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies. BMC Med Res Methodol. 2023 May 27;23(1):131. PUBMED ID: 37245005

Mao et al. Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice. Front Physiol. 2023 Mar 30;14:1109452. PUBMED ID: 37064885

Hammond et al. The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease. J Vet Intern Med. 2023 Mar 23. PUBMED ID: 36951394

Ortiz et al. Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1. Cell Rep. 2023 Feb 28;42(2):112059.  PUBMED ID: 36729833

Sotillo et al. Dose-response of benazepril on biomarkers of the classical and alternative pathways of the renin-angiotensin-aldosterone system in dogs. Sci Rep. 2023 Feb 15;13(1):2684. PUBMED ID: 36792677

Bosch et al. Angiotensin pathways under therapy with empagliflozin in patients with chronic heart failure. ESC Heart Fail. 2023 Feb 13. PUBMED ID: 36782339

Hartl et al. The systemic and hepatic alternative renin-angiotensin system is activated in liver cirrhosis, linked to endothelial dysfunction and inflammation. Sci Rep. 2023 Jan 18;13(1):953. PUBMED ID: 36653504

Publications 2022

Reindl-Schwaighofer et al. The systemic renin-angiotensin system in COVID-19. Sci Rep. 2022 Nov 22;12(1):20117. PUBMED: 36418458

Briand et at. Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden Hamsters. Viruses. 2022 Sep 17;14(9):2067. PUBMED: 36146875

Cruz-López et al. Blood pressure-independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes. Br J Pharmacol. 2022 Sep 15. PUBMED: 36106615

Simko et at. Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin-Angiotensin-Aldosterone System. Biomedicines. 2022 Jul 31;10(8):1844. PUBMED: 36009391

Dörr et al. The Effect of FGF23 on Cardiac Hypertrophy Is Not Mediated by Systemic Renin-Angiotensin- Aldosterone System in Hemodialysis. Front Med (Lausanne). 2022 Apr 26;9:878730. PUBMED: 35559350 

Krenn et al. The Renin-Angiotensin System as a Component of Biotrauma in Acute Respiratory Distress Syndrome. Front. Physiol., 13 April 2022. PUBMED: 35498160

Lourenco et at. Characterization of the intrarenal renin-angiotensin system in cats with naturally occurring chronic kidney disease. J Vet Intern Med. 2022 Mar;36(2):647-655. PUBMED: 35352404

Ward et al. Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy. J Vet Intern Med. 2022 Mar 14. PUBMED: 35285549

Mao et al. Tidal Volume-Dependent Activation of the Renin-Angiotensin System in Experimental Ventilator-Induced Lung Injury. Crit Care Med. 2022 Feb 22. PUBMED: 35191411

Wang et al. Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries. Hypertension . 2022 Feb;79(2):365-378. PUBMED ID: 34844421

Antlanger et al. Combined SGLT-2 and ACE inhibition upregulates the renin-angiotensin system in chronic kidney disease with type 2 diabetes: Results of a randomized, double-blind, placebo-controlled exploratory trial. Diabetes Obes Metab. 2022 Jan 4. PUBMED ID: 34984822

Publications 2021

Evans et al. Suspected primary hyperreninism in a cat with malignant renal sarcoma and global renin-angiotensin-aldosterone system upregulation. J Vet Intern Med. 2021 Dec 3. PUBMED ID: 34859924

Krenn et al. Equilibrium Angiotensin Metabolite Profiling in Patients with Acute Respiratory Distress Syndrome Indicates Angiotensin-Converting Enzyme Inhibition. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1468-1471. PUBMED ID: 32628511

Kovarik et al. Effect of Mineralocorticoid Receptor Antagonism and ACE Inhibition on Angiotensin Profiles in Diabetic Kidney Disease: An Exploratory Study. Diabetes Ther. 2021 Sep;12(9):2485-2498. PUBMED ID: 34351585

Alves-Lopes et al. Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension. Hypertension. 2021 Sep;78(3):604-616. PUBMED ID: 34304582

van Rooyen et al. Aldosterone and angiotensin II profiles in young black and white women using different hormonal contraceptives: the African-PREDICT study. J Hum Hypertens. 2021 Jun 25. PUBMED ID: 34172825

Binder et al. Renin Feedback Is an Independent Predictor of Outcome in HFpEF. J Pers Med. 2021 May 3;11(5):370. PUBMED ID: 34063595

Nonn et at. Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia. Hypertension. 2021 May 5;77(5):1723-1736. PUBMED ID: 33775117

Kukida et al. Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-Infused Mice. J Am Heart Assoc. 2021 May 4;10(9):e020467. PUBMED ID: 33890483

Pavo et al. Myocardial Angiotensin Metabolism in End-Stage Heart Failure. J Am Coll Cardiol. 2021 Apr 13;77(14):1731-1743. PUBMED ID: 33832600

Bovée et al. Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease. Hypertension. 2021 May 5;77(5):1600-1612. PUBMED ID: 33719507

Vischer et al. Influence of Antihypertensive Treatment on RAAS Peptides in Newly Diagnosed Hypertensive Patients. Cells. 2021 Mar 3;10(3):534. PUBMED ID: 33802464

Carrocia et al. Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex. J Hypertens. 2021 Mar 1. PUBMED ID: 33657582

Reindl-Schwaighofer et al. Angiotensin-Converting Enzyme 2 (ACE2) Elevation in Severe COVID-19. Am J Respir Crit Care Med. 2021 Feb 18. PUBMED ID: 33600742

van Lier et al. Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients. ERJ Open Res. 2021 Mar 15;7(1):00848-2020. PUBMED ID: 33738305

Batchu et al. Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19. Diabetes. 2021 Mar;70(3):759-771 PUBMED ID: 33310740

Kutz et al. Renin-Angiotensin-Aldosterone System peptide profiles in patients with COVID-19. Eur J Endocrinol. 2021 Feb 1;EJE-20-1445.R1 PUBMED ID: 33539316

Uijl et al. No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension. Clin Sci (Lond). 2021 Jan 6;CS20201239. PUBMED ID: 33404046

Publications 2020

Huh et al. Effect of angiotensin receptor blockers and angiotensin-converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in cats with heart disease. J Vet Intern Med. 2020 Nov 2. PUBMED ID: 33135833

Gafane-Matemane et al. Associations of central and peripheral blood pressure with the renin-angiotensin-aldosterone system in healthy young adults: the African-PREDICT study. Hypertens Res. 2020 Oct 30. PUBMED ID: 33122821

Zoufaly et al. Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. September 24, 2020. doi.org/10.1016/
S2213-2600(20)30418-5.

Kintscher et al. Plasma Angiotensin Peptide Profiling and ACE (Angiotensin-Converting Enzyme)-2 Activity in COVID-19 Patients Treated With Pharmacological Blockers of the Renin-Angiotensin System. Hypertension. 2020 Nov;76(5):e34-e36. doi: 10.1161/HYPERTENSIONAHA.120.15841. PUMBED ID: 32851897

De Souza et al. Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats. J Am Heart Assoc. 2020 Jul 21;9(14):e017246. PUBMED ID: 32674648

Messmann et al. Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support. Mol Cell Biochem. 2020 Jun 20. doi: 10.1007/s11010-020-03787-7 PUBMED ID: 32564294

Krenn et al. Equilibrium Angiotensin Metabolite Profiling in Patients with Acute Respiratory Distress Syndrome Indicates Angiotensin Converting Enzyme Inhibition. Am J Respir Crit Care Med. 2020 Jul 6. doi: 10.1164/rccm.201912-2504LE PUBMED ID: 32628511

Wang et al. Elevated Angiotensin 1-7/Angiotensin II Ratio Predicts Favorable Outcomes in Patients With Heart Failure. Circ Heart Fail. 2020 Jul;13(7):e006939. doi: 10.1161/CIRCHEARTFAILURE.120.006939. Epub 2020 Jun 25. PUBMED ID: 32580658

Shalinee et al. Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice. J Biol Chem. 2020 Jun 16;jbc.RA120.014183. doi: 10.1074/jbc.RA120.014183. PUBMED ID: 32546481

Guo et al. Effects of Ramipril on the Aldosterone/Renin Ratio and the Aldosterone/Angiotensin II Ratio in Patients With Primary Aldosteronism. Hypertension. 2020 Jun 8;HYPERTENSIONAHA12014871. PUBMED ID: 32507039

Kaltenecker et al. Critical Role of Neprilysin in Kidney Angiotensin Metabolism. Circ Res. 2020 May 18. doi: 10.1161/CIRCRESAHA.119.316151. PUBMED ID: 32418507

Urwyler et al. IL (Interleukin)-1 Receptor Antagonist Increases Ang (Angiotensin [1-7]) and Decreases Blood Pressure in Obese Individuals. Hypertension. 2020 Jun;75(6):1455-1463. PUBMED ID: 32275191

Guo et al. Measurement of Equilibrium Angiotensin II in the Diagnosis of Primary Aldosteronism. Clin Chem. 2020 Mar 1;66(3):483-492. PUBMED ID: 32068832 

Adin et al. Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism. J Vet Intern Med. 2020 Feb 29. PUBMED ID: 32112596 

Publications 2019

Manis et al. Relationship Between Renin-Angiotensin-Aldosterone System and Renal Kir5.1 Channels. Clin Sci (Lond). 2019;CS20190876. 2019 Dec 4 PUBMED ID: 31799617

Potter et al. Comparison between the effects of torsemide and furosemide on the renin-angiotensin-aldosterone system of normal dogs. J Vet Cardiol. 2019 Dec;26:51-62. doi: 10.1016/j.jvc.2019.11.003. Epub 2019 Nov 14. PUBMED ID: 31809955 

Burrello et al. Renin-Angiotensin-Aldosterone System Triple-A Analysis for the Screening of Primary Aldosteronism. Hypertension HYPERTENSIONAHA11913772 2019 Nov 25 PUBMED ID: 31760886

van Rooyen et al. A Primary Aldosteronism-Like Phenotype Identified With the Aldosterone-To-Angiotensin II Ratio in Black Men. The SABPA StudyCardiovasc J Afr, 30, 1-6 2019 Nov 27. PUBMED ID: 31781716

Göppner et al. Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism. Nat Commun. 2019 Oct 15;10(1):4678. PUBMED ID: 31615979 

El Zein et al. Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling. Sci Rep. 2019 Oct 11;9(1):14677. doi: 10.1038/s41598-019-50988-2. PUBMED ID: 31605007

Arendse et al. Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure. Pharmacol Rev. 2019 Oct;71(4):539-570. doi: 10.1124/pr.118.017129. PUBMED ID: 31537750 

Kovarik et al. Intrarenal Renin-Angiotensin-System Dysregulation after Kidney Transplantation. Sci Rep. 2019 Jul 5;9(1):9762. doi: 10.1038/s41598-019-46114-x. PUBMED ID: 31278281

Binder et al. Angs (Angiotensins) of the Alternative Renin-Angiotensin System Predict Outcome in Patients With Heart Failure and Preserved Ejection Fraction. Hypertension. 2019 Jun 24:HYPERTENSIONAHA11912786. doi: 10.1161/HYPERTENSIONAHA.119.12786. PUBMED ID: 31230551

Larouche-Lebel et al. Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease. J Vet Intern Med. 2019 Jun 28. doi: 10.1111/jvim.15548. PUBMED ID: 31254308

Wang et al. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13006-13015. doi: 10.1073/pnas.1900152116. Epub 2019 Jun 12. PUBMED ID: 31189595 

Caroccia et al. Aldosterone Stimulates Its Biosynthesis Via A Novel GPER Mediated Mechanism. J Clin Endocrinol Metab. 2019 May 24. pii: jc.2019-00043. doi: 10.1210/jc.2019-00043. PUBMED ID: 31125081

Wolf et al. Identifying a disease specific renin-angiotensin-aldosterone system fingerprint in patients with primary adrenal insufficiency. Eur J Endocrinol. 2019 May 1. pii: EJE-19-0086.R1. doi: 10.1530/EJE-19-0086. PUBMED ID: 31075757

Uijl et al. Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen. Hypertension. 2019 Jun;73(6):1249-1257. doi: 10.1161/HYPERTENSIONAHA.119.12703. PUBMED ID: 31030610

Kopecky et al. Molecular regulation of the renin-angiotensin system by sodium-glucose cotransporter 2 inhibition in type 1 diabetes mellitus. Diabetologia. 2019 Apr 11. doi: 10.1007/s00125-019-4871-8. PUBMED ID: 30976852

Ames et al. The renin-angiotensin-aldosterone system and its suppression. J Vet Intern Med. 2019 Mar;33(2):363-382. doi: 10.1111/jvim.15454. Epub 2019 Feb 26. PUBMED ID: 30806496

Ilatovskaya et al. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). EBioMedicine. 2019 Feb;40:663-674. doi: 10.1016/j.ebiom.2019.01.006. Epub 2019 Feb 8. PUBMED ID: 30745171

Gatineau et al. Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H506-H515. doi: 10.1152/ajpheart.00473.2018. Epub 2018 Dec 14. PUBMED ID: 30550352 

Blass et al. Postprandial Effects on ENaC-Mediated Sodium Absorption. Sci Rep. 2019 Mar 12;9(1):4296. doi: 10.1038/s41598-019-40639-x. PUBMED ID: 30862903

Publications 2018

Sharp et al. Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System. J Am Coll Cardiol. 2018 Nov 27;72(21):2609-2621. doi: 10.1016/j.jacc.2018.08.2186. PUBMED ID: 30466519

Simko et al. Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension. Int J Mol Sci. 2018 Oct 3;19(10). pii: E3017. doi: 10.3390/ijms19103017. PUBMED ID:  30282928 

Simko et al. Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension. Molecules. 2018 Jan 29;23(2). pii: E265. doi: 10.3390/molecules23020265. PUBMED ID: 29382124

Guo et al. Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism.J Clin Endocrinol Metab. 2018 Nov 1;103(11):3965-3973. doi: 10.1210/jc.2018-01041. PUBMED ID: 30137438

Bennion et al. Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach. Clin Sci (Lond). 2018 Mar 15;132(5):581-593. doi: 10.1042/CS20180100. Print 2018 Mar 15. PUBMED ID:  29500223

Publications 2017

Stowasser et al. Can Screening and Confirmatory Testing in the Management of Patients with Primary Aldosteronism be Improved? Horm Metab Res. 2017 Dec;49(12):915-921. doi: 10.1055/s-0043-121468. Epub 2017 Nov 13. PUBMED ID: 29132172

Pavo et al. Low- and High-renin Heart Failure Phenotypes with Clinical Implications. Clin Chem. 2017 Nov 14. pii: clinchem.2017.278705. doi: 10.1373/clinchem.2017.278705. PUBMED ID: 29138270

Xu et al. Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension. Circ Res. 2017 May 16. pii: CIRCRESAHA.116.310509. doi: 10.1161/CIRCRESAHA.116.310509. PUBMED ID: 28512108

Carrocia et al. Urotensin II Exerts Pressor Effects By Stimulating Renin And Aldosterone Synthase Gene Expression. Sci Rep. 2017 Oct 24;7(1):13876. doi: 10.1038/s41598-017-12613-y. PUBMED ID: 29066763

Antlanger et al. Molecular remodeling of the renin-angiotensin system after kidney transplantation. J Renin Angiotensin Aldosterone Syst. 2017 Apr-Jun;18(2):1470320317705232. doi: 10.1177/1470320317705232. PUBMED ID: 28490223

van Thiel et al. Brain Renin-Angiotensin System: Does It Exist? Hypertension. 2017 Apr 10. pii: HYPERTENSIONAHA.116.08922. doi: 10.1161/HYPERTENSIONAHA.116.08922. PUBMED ID: 28396529

Antlanger et al. Effects of Direct Renin Inhibition versus Angiotensin II Receptor Blockade on Angiotensin Profiles in Non-Diabetic Chronic Kidney Disease. Ann Med. 2017 Mar 30:1-24. doi: 10.1080/07853890.2017.1313447. PUBMED ID: 28358246

Reichhart et al. Hypertensive retinopathy in a transgenic angiotensin-based model. Clin Sci (Lond). 2016 Jul 1;130(13):1075-88. doi: 10.1042/CS20160092. PUBMED ID: 27026533

Motta-Santos et al. Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res. 2016 Jul;39(7):506-12. doi: 10.1038/hr.2016.28. PUBMED ID: 27053009

Basu R et al. Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure. J Am Coll Cardiol. 2017 Feb 21;69(7):805-819. 
DOI: 10.1016/j.jacc.2016.11.064. PUBMED ID: 28209222

Publications 2016

Pavo N et al. Renin-Angiotensin System Fingerprints of Heart Failure With Reduced Ejection Fraction. J Am Coll Cardiol. 2016 Dec 27;68(25):2912-2914.
DOI: 10.1016/j.jacc.2016.10.017. PUBMED ID: 28007153

van Rooyen JM et al. Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint®. J Renin Angiotensin Aldosterone Syst. 2016 Oct 12;17(4)
DOI: 10.1177/1470320316669880. PUBMED ID: 27737932

Poglitsch et al. Letter to the editor: Angiotensin quantification by mass spectrometry. Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H452-3. doi: 10.1152/ajpheart.00933.2015. PUBMED ID: 26830339

Domenig O et al. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Sci Rep. 2016 Sep 21;6:33678.
DOI: 10.1038/srep33678. PUBMED ID: 27649628

Kovarik JJ et al. Effects of angiotensin-converting enzyme inhibitor therapy on the regulation of plasma and cardiac tissue renin-angiotensin system in heart transplant patients. J of Heat and Lung Transplantation. Published online 2016 Sep 09.
DOI: j.healun.2016.08.022.

Publications 2015

Sabharwal R et al. Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy. Exp Physiol. 2015 Jul 1;100(7):776-95.
DOI: 10.1113/EP085066. PUBMED ID: 25921929

Roksnoer LC et al. Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats. Kidney Int. 2015 Jul;88(1):109-20.
DOI: 10.1038/ki.2015.107. Epub 2015 Apr 1. PUBMED ID: 25830765

Wysocki J et al. Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis. Am J Hypertens. 2015 Dec; 28(12):1418-26.
DOI: 10.1093/ajh/hpv054. Epub 2015 May 11. PUBMED ID: 25968123

Sharp S et al. Pharmacodynamic effects of C-domain-specific ACE inhibitors on the renin-angiotensin system in myocardial infarcted rats. J Renin Angiotensin Aldosterone Syst. 2015 Mar 9.
pii: 1470320314568438. PUBMED ID: 25757657

Kovarik JJ et al. Molecular regulation of the renin-angiotensin system in haemodialysis patients. Nephrol Dial Transplant. 2015 Jan;30(1):115-23.
DOI: 10.1093/ndt/gfu265; PUBMED ID: 25107336

Andersen LB et al. Vitamin D depletion aggravates hypertension and target-organ damage. J Am Heart Assoc. 2015 Jan 28;4(2).
DOI: 10.1161/JAHA.114.001417; PUBMED ID: 25630909

Publications 2014

Manzel A et al. Angiotensin IV is induced in experimental autoimmune encephalomyelitis but fails to influence the disease. J Neuroimmune Pharmacol. 2014 Sep;9(4):533-43.
DOI: 10.1007/s11481-014-9548-y; PUBMED ID: 24854706

Burger D et al. Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension. Clin Sci (Lond). 2014 Jul;127(1):57-63.
DOI: 10.1042/CS20130808. PUBMED ID: 24506807

Haber PK et al. Angiotensin-converting enzyme 2-independent action of presumed angiotensin-converting enzyme 2 activators: studies in vivo, ex vivo, and in vitro. Hypertension. 2014 Apr;63(4):774-82.
DOI: 10.1161/HYPERTENSIONAHA.113.02856. Epub 2014 Jan 20. PUBMED ID: 24446061

Publications 2013

Haschke M et al. Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet. 2013 Sep;52(9):783-92.
DOI: 10.1007/s40262-013-0072-7; PUBMED ID: 23681967

Nikolaou A et al. [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase. Eur J Pharmacol. 2013 Feb 28;702(1-3):93-102.
DOI: 10.1016/j.ejphar.2013.01.026. Epub 2013 Jan 31. PUBMED ID: 23376157

Publications 2012

Poglitsch M et al. Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System. Int J Hypertens. 2012;2012:428950.
DOI: 10.1155/2012/428950; PUBMED ID: 22518284

Ye M et al. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension. 2012 Sep;60(3):730-40.
DOI: 10.1161/HYPERTENSIONAHA.112.198622; PUBMED ID: 22777933